Despite their best efforts, the Simpsons completely vexed Dr. Marvin Monroe (though, to be fair, Dr. Marvin Monroe advertised on TV, so how good could he have been, really?) to the point where he vanished and eventually died; in “Animaniacs”, Yakko, Wakko, and Dot Warner made Dr. Scratchensnif pull out his hair and eventually give up in defeat. Both shows were really funny in how they handled their respective storylines.
Don’t kick the baby!