I consider this to potentially be very good news depending on how it holds up in further study. It could lead to new therapeutics and perhaps new vaccine approaches.
Human-IgG-Neutralizing Monoclonal Antibodies Block the SARS-CoV-2 Infection from the Abstract (so can be shared):
Wan et al. identify 11 potent neutralizing antibodies against COVID-19 from 11 convalescent patients. These human neutralizing antibodies target three separate epitopes on the receptor binding domain (RBD) of the SARS-CoV-2 spike protein, and epitope-B antibody (553-15) can enhance the neutralizing abilities of most other antibodies.
Highlights
11 neutralizing antibodies against SARS-CoV-2 target three main epitopes on RBD
Epitope-A antibody 414-1 shows neutralizing IC50 at 1.75 nM
Epitope-B antibody 553-15 can enhance the neutralizing
abilities of other antibodies
One neutralizing antibody, 515-5, can cross neutralize SARS- CoV pseudovirus
I consider this to potentially be very good news depending on how it holds up in further study. It could lead to new therapeutics and perhaps new vaccine approaches.
https://www.cell.com/cell-reports/pdf/S2211-1247(20)30899-8.pdf
which is a new Journal article in Cell titled
Human-IgG-Neutralizing Monoclonal Antibodies Block the SARS-CoV-2 Infection from the Abstract (so can be shared):
Wan et al. identify 11 potent neutralizing antibodies against COVID-19 from 11 convalescent patients. These human neutralizing antibodies target three separate epitopes on the receptor binding domain (RBD) of the SARS-CoV-2 spike protein, and epitope-B antibody (553-15) can enhance the neutralizing abilities of most other antibodies.
Highlights
11 neutralizing antibodies against SARS-CoV-2 target three main epitopes on RBD
Epitope-A antibody 414-1 shows neutralizing IC50 at 1.75 nM
Epitope-B antibody 553-15 can enhance the neutralizing
abilities of other antibodies
One neutralizing antibody, 515-5, can cross neutralize SARS- CoV pseudovirus